Monday, January 09, 2006

Article: HIV seroconversion among IDUs

"The Impact of Sex Partners' HIV Status on HIV Seroconversion in a Prospective Cohort of Injection Drug Users" Journal of Acquired Immune Deficiency Syndromes Vol. 41; No. 1: P. 119-123 (01.01.06):: Thomas Kerr, PhD; Jo-Anne Stoltz, PhD; Steffanie Strathdee, PhD; Evan Wood, PhD

The identification of persons at highest risk for HIV infection is crucial for targeting prevention strategies, the authors noted. In this study, researchers evaluated the HIV status of injection drug users' (IDUs) sex partners and rates of subsequent seroconversion among participants of the prospective Vancouver Injection Drug Users Study.

Of 1,013 IDUs who were HIV-negative at baseline, 4.8 percent reported having an HIV-positive sex partner. Kaplan-Meier methods were used to estimate cumulative HIV incidence. After 18 months, the cumulative HIV incidence rate was significantly elevated among those reporting having an HIV-positive sex partner (23.4 percent vs. 8.1 percent; log-rank P less than 0.001). In a Cox regression model adjusting for all variables associated with time to HIV infection in univariate analyses, including drug use characteristics, having an HIV-positive partner was independently associated with time to seroconversion (relative hazard=2.42 [95 percent confidence interval: 1.30 to 4.60]; P=0.005).

"Having an HIV-positive sex partner was strongly and independently associated with seroconversion after adjustment for risk factors related to drug use," concluded researchers. "Our findings may aid public health workers in their efforts to identify IDUs who should be targeted with education and prevention efforts and indicate the need for ongoing development of prevention interventions for IDU sex partners who are HIV discordant."

[from CDC news]

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