What's Next? Treatment Options When the First Antiretroviral Regimen Fails Virologically or Is Not Tolerated, Part 1
Peter J. Ruane, MB, MRCP; Eric S. Daar, MD
There are many choices for the initial treatment of HIV infection. However, a change may be required if drug resistance or intolerance occurs. Thus, the selection of an initial regimen is important not only because of its immediate effects but also because of its potential influence on subsequent treatment options. HIV clinicians should be aware of the resistance and safety profiles of the regimens they prescribe as initial therapy and be ready with a strategy for subsequent treatment in the event of virologic failure or drug toxicity. This article suggests treatment algorithms for those experiencing adverse events or the emergence of drug resistance with commonly used antiretroviral regimens.